Abstract
Objective
Prior data suggest paternal or sibling stroke was associated with increased risk of
offspring stroke. Whether family history of cardiovascular disease (FHc) predicts
risk of stroke recurrence remains unclear, we aim to determine this issue on patients
with ischemic stroke (IS) or transient ischemic attack (TIA).
Materials and Methods
This is a post hoc analysis based on the Third China National Stroke Registry III.
IS/TIA patients with data of FHc status were included. FHc was defined as family history
of coronary heart disease (CHD) or stroke among first-degree relatives (include parents,
children, and siblings (same parents)). Cox proportional hazards regression models
were performed to assess the association between FHc and recurrent events at 1 year
follow-up.
Results
Totally 14,208 patients with verified FHc status were included, 4,454 (31.3%) were
female and the median (IQR) age was 62.0 (54.0, 70.0) years. Of these, 294 (2.1%),
726 (5.1%) and 1936 (13.6%) had family history of both CHD and stroke, family history
of CHD, and family history of stroke only, respectively. Using multivariable Cox models
adjusted for age, sex, and vascular risk factors, we found that patients with FHc
experienced higher risk of stroke recurrence (HR=1.151, 95%CI=1.000-1.324) and combined
vascular events (HR=1.186, 95%CI=1.036-1.358) at 1 year compared with those without
FHc. In sensitivity analysis on patients who received primary secondary prevention
treatment of antiplatelet and statins, the association persisted.
Conclusions
FHc is associated with increased risk of stroke recurrence even under primary secondary
prevention treatment.
Key Words
Abbreviation:
CNSR III (the Third China National Stroke Registry), FHc (family history of cardiovascular disease), TIA (transient ischemic attack), IS (ischemic stroke), BMI (body mass index), CHD (coronary heart disease), LDL (low-density lipoprotein cholesterol), HDL (high-density lipoprotein cholesterol), TG (triglycerides), SBP (systolic blood pressure), FPG (fasting plasma glucose)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: November 22, 2021
Accepted:
September 29,
2021
Received in revised form:
September 25,
2021
Received:
July 18,
2021
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106151
Copyright
© 2021 Elsevier Inc. All rights reserved.
