Abstract
Objectives
The nerve damage and cognitive impairment caused by intracerebral hemorrhage (ICH)
seriously affect the quality of life of patients. Cordycepin has been reported to
have antioxidant and neuroprotective functions. However, the therapeutic effect of
cordycepin on cognitive impairment caused by ICH is still unclear.
Materials and methods
Autologous whole blood was injected into the basal ganglia to construct a mouse ICH
model. The Modified Neurological Severity Score was used to assess nerve damage in
mice. The wet/dry method was used to detect brain water content. Open field test was
used to assess the anxiety of mice. Morris water maze testing, Y-maze test and nest-building
test were used to evaluate the cognitive function of mice. qRT-PCR and western blotting
assay were used to evaluate the expression of genes.
Results
Cordycepin treatment could ameliorate ICH-induced neurological deficits, brain edema,
anxiety, cognitive impairments, oxidative stress and antioxidant capacity in ICH mice.
Conclusion
Cordycepin ameliorates ICH-induced neurological and cognitive impairments through
reducing anti-oxidative stress in mouse model.
Key Words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Stroke and Cerebrovascular DiseasesAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Recent advances in spontaneous intracerebral hemorrhage.F1000Res. 2019; 8 (F1000 Faculty Rev 302)
- Intracerebral hemorrhage: an update on diagnosis and treatment.Expert Rev Neurother. 2019; 19: 679-694
- Diagnosis and management of acute intracerebral hemorrhage.Emerg Med Clin N Am. 2016; 34: 883-899
- Management of spontaneous intracerebral hemorrhage.Curr Neurol Neurosci Rep. 2017; 17: 80
- Intracerebral hemorrhage outcome: a comprehensive update.J Neurol Sci. 2019; 398: 54-66
- Cognitive impairment before and after intracerebral haemorrhage: a systematic review.Neurol Sci. 2020; 41: 509-527
- Association of cerebral small vessel disease and cognitive decline after intracerebral hemorrhage.Neurology. 2021; 96: e182-e192
- Cordycepin in anticancer research: molecular mechanism of therapeutic effects.Curr Med Chem. 2020; 27: 983-996
- [Advances in biosynthesis of cordycepin from Cordyceps militaris].Sheng Wu Gong Cheng Xue Bao. 2020; 36: 1293-1304
- Functional study of Cordyceps sinensis and cordycepin in male reproduction: a review.J Food Drug Anal. 2017; 25: 197-205
- Cordycepin protects against cerebral ischemia/reperfusion injury in vivo and in vitro.Eur J Pharmacol. 2011; 664: 20-28
- Cordycepin confers neuroprotection in mice models of intracerebral hemorrhage via suppressing NLRP3 inflammasome activation.Metab Brain Dis. 2017; 32: 1133-1145
- RNF34 overexpression exacerbates neurological deficits and brain injury in a mouse model of intracerebral hemorrhage by potentiating mitochondrial dysfunction-mediated oxidative stress.Sci Rep. 2019; 9: 16296
- Intravenous administration of human adipose-derived stem cells ameliorates motor and cognitive function for intracerebral hemorrhage mouse model.Brain Res. 2019; 1711: 58-67
- Mesenchymal stem cell-derived extracellular vesicles ameliorates hippocampal synaptic impairment after transient global ischemia.Front Cell Neurosci. 2017; 11: 205
- Cognitive reserve and long-term change in cognition in aging and preclinical Alzheimer's disease.Neurobiol Aging. 2017; 60: 164-172
- The growing clinical spectrum of cerebral amyloid angiopathy.Curr Opin Neurol. 2018; 31: 28-35
- Brain hemorrhage recurrence, small vessel disease type, and cerebral microbleeds: a meta-analysis.Neurology. 2017; 89: 820-829
- Cerebral Amyloid Angiopathy.StatPearls, Treasure Island (FL)2021
- [Clinical medication characteristics of shuxuening injection in treatment of cerebral infarction research based on registration].Zhongguo Zhong Yao Za Zhi. 2016; 41: 4516-4520
- Stem cell therapy: a promising therapeutic method for intracerebral hemorrhage.Cell Transplant. 2018; 27: 1809-1824
- Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation.Lancet Neurol. 2020; 19: 1023-1032
- Mechanism of activation of AMPK by Cordycepin.Cell Chem Biol. 2020; 27 (e214): 214-222
- Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress.Eur J Pharmacol. 2018; 818: 110-114
- Cordycepin attenuates traumatic brain injury-induced impairments of blood-brain barrier integrity in rats.Brain Res Bull. 2016; 127: 171-176
- Cordycepin (3′-deoxyadenosine) attenuates age-related oxidative stress and ameliorates antioxidant capacity in rats.Exp Gerontol. 2012; 47: 979-987
- The neuroprotective effects of cordycepin inhibit glutamate-induced oxidative and ER stress-associated apoptosis in hippocampal HT22 cells.Neurotoxicology. 2014; 41: 102-111
- Microglial activation and chronic neurodegeneration.Neurotherapeutics. 2010; 7: 354-365
Article info
Publication history
Published online: November 11, 2021
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106199
Copyright
© 2021 Elsevier Inc. All rights reserved.
