Abstract
Objectives
There is accumulating evidence that periodontal disease is associated with atrial
fibrillation (AF) or stroke, but it is unclear which causative species of periodontal
disease are present in stroke patients with AF. We aimed to investigate the associations
between AF and specific periodontal pathogens using serum titers of IgG antibodies
of bacteria in acute stroke patients.
Materials and methods
Acute stroke patients were registered at two hospitals. Serum samples were evaluated
for titers of antibodies against 9 periodontal pathogens (16 genotypes) using ELISAs.
We identified AF in patients according to the following criteria: (1) a history of
sustained or paroxysmal AF or (2) AF detection upon arrival or during admission. We
carried out propensity score matching to categorize the patients as those with AF
and those without.
Results
Of the 664 acute stroke patients, 123 (18.5%) had AF. After propensity score matching,
234 patients were selected. Patients with AF had a higher prevalence of positive serum
titers of antibodies against Porphyromonas gingivalis (FimA type III) and Porphyromonas gingivalis (FimA type V) than those without AF (59.0% vs. 39.3%, p=0.004 and 58.2% vs. 40.2%,
p=0.009, respectively).
Conclusions
Porphyromonas gingivalis, especially FimA type III and type V, might be associated with AF in stroke patients.
Key Words
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References
- Periodontal disease and systemic conditions: a bidirectional relationship.Odontology. 2006; 94: 10-21https://doi.org/10.1007/s10266-006-0060-6
- Systemic effects of periodontitis: epidemiology of periodontal disease and cardiovascular disease.J Periodontol. 2005; 76: 2089-2100https://doi.org/10.1902/jop.2005.76.11-S.2089
- Periodontal disease and stroke: a meta-analysis of cohort studies.Eur J Neurol. 2014; 21 (e1166-1157): 1155-1161https://doi.org/10.1111/ene.12415
- Risk of atrial fibrillation or flutter associated with periodontitis: a nationwide, population-based, cohort study.PLoS One. 2016; 11e0165601https://doi.org/10.1371/journal.pone.0165601
- Periodontal disease, atrial fibrillation and stroke.Am Heart J. 2021; 235: 36-43https://doi.org/10.1016/j.ahj.2021.01.009
- Porphyromonas gingivalis: where do we stand in our battle against this oral pathogen?.RSC Med Chem. 2021; 12: 666-704https://doi.org/10.1039/d0md00424c
- Serum immunoglobulin G antibody titer to Fusobacterium nucleatum is associated with unfavorable outcome after stroke.Clin Exp Immunol. 2020; 200: 302-309https://doi.org/10.1111/cei.13430
- Special report from the National Institute of Neurological Disorders and Stroke. Classification of cerebrovascular diseases III.Stroke. 1990; 21: 637-676
- Involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease.J Gastroenterol. 2018; 53: 269-280https://doi.org/10.1007/s00535-017-1368-4
- Relationship of subgingival microbial complexes to clinical features at the sampled sites.J Clin Periodontol. 1988; 15: 440-444https://doi.org/10.1111/j.1600-051x.1988.tb01598.x
- Association of serum anti-periodontal pathogen antibody with ischemic stroke.Cerebrovasc Dis. 2012; 34: 385-392https://doi.org/10.1159/000343659
- Serum IgG titers against periodontal pathogens are associated with cerebral hemorrhage growth and 3-month outcome.PLoS One. 2020; 15e0241205https://doi.org/10.1371/journal.pone.0241205
- Association between periodontal disease due to Campylobacter rectus and cerebral microbleeds in acute stroke patients.PLoS One. 2020; 15e0239773https://doi.org/10.1371/journal.pone.0239773
- Serum IgG titers to periodontal pathogens predict 3-month outcome in ischemic stroke patients.PLoS One. 2020; 15e0237185https://doi.org/10.1371/journal.pone.0237185
- Molecular cloning and sequencing of the gene encoding the fimbrial subunit protein of Bacteroides gingivalis.J Bacteriol. 1988; 170: 1658-1665https://doi.org/10.1128/jb.170.4.1658-1665.1988
- The prevalence of fimA genotypes of Porphyromonas gingivalis in patients with chronic periodontitis: A meta-analysis.PLoS One. 2020; 15e0240251https://doi.org/10.1371/journal.pone.0240251
- Distribution of Porphyromonas gingivalis fimA genotypes in cardiovascular specimens from Japanese patients.Oral Microbiol Immunol. 2008; 23: 170-172https://doi.org/10.1111/j.1399-302X.2007.00406.x
Article info
Publication history
Published online: January 13, 2022
Accepted:
December 24,
2021
Received in revised form:
December 2,
2021
Received:
September 8,
2021
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106301
Copyright
© 2021 Elsevier Inc. All rights reserved.
