Abstract
Background and Purpose
Fecal microbiota transplantation (FMT) is a novel microbiota-based therapeutic method
that transfers stool from donor into a recipient and its application is under investigating
for neurological disorders such as stroke. In this systematic review, we assessed
the effect of FMT in progression and treatment of stroke and recovery of post-stroke
complications.
Methods
Preliminary studies were searched in MEDLINE via PubMed, Scopus, COCHRANE library
and Google Scholar, databases up to February 2022. The search strategy was restricted
to articles about FMT in stroke. The initial search yielded 4570 articles, of which
19 publications were included in our systematic review.
Results
Based on outcomes transferring microbiome from healthy or ischemic donor to other
ischemic recipient can affect brain infarct volume and survival rate, neurological
and behavioral outcomes, and inflammatory pathways.
Conclusions
Our systematic review on preclinical studies showed that manipulating gut microbiota
via FMT can be a possible therapeutic approach for treatment of stroke and recovery
of post-stroke complications.
Keyword
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Article info
Publication history
Published online: September 23, 2022
Accepted:
August 14,
2022
Received:
April 10,
2022
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106727
Copyright
© 2022 Elsevier Inc. All rights reserved.
