Highlights
- •Subtle relationship between CCD and patient prognosis.
- •Poor collateral circulation represents microcirculation disorders.
- •The collateral grade can affect the occurrence of CCD.
- •Neurovascular interaction may be involved in the mechanism of CCD.
Abstract
Objectives
It has not been reported whether collateral circulation, a factor closely related
to the prognosis of patients with cerebral infarction, is related to the occurrence
of crossed cerebellar diaschisis(CCD) or not. Our research attempts to verify the
relationship between the collateral circulation grade and the occurrence of CCD, mainly
by means of CTA and CTP.
Materials and methods
A total of 47 patients were divided into a CCD-positive (Kim et al., 2019) or a CCD-negative
group Furlanis et al. (2018) by calculating the asymmetry index (AI) value (<10%)
of bilateral cerebellar cerebral blood flow (CBF). A 4-scale grading method was used
to evaluate collateral circulation in the supratentorial infarct area, and the four
perfusion parameters of the supratentorial and subtentorial brain regions were analyzed
and compared between the two groups. The extent of vascular lesions was evaluated
by MR sequences including DWI and MRA.
Results
Among the four perfusion parameters, except for CBV, were significantly different
between the bilateral cerebellum in the CCD-positive group, but only TTP in the supratentorial
cerebral infarction area was statistically different in the two groups. Moreover,
the collateral circulation sore in the CCD-positive group was significantly lower
than that in the CCD-negative group. But no statistical difference was found in the
comparison of DWI positive rates between the two groups.
Conclusion
The collateral score in the supratentorial infarct area is correlated with the occurrence
of CCD,which may be used to explain the effect of CCD on the prognosis of patients.
Keywords
Abbreviations:
CCD (crossed cerebellar diaschisis), CPC (cortico-ponto-cerebellar), AIF (arterial input function), AI (asymmetry index), CTC (cerebello-thalamo-cortical), CCR (cerebral circulation reserves), CG (collateral grade)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: October 26, 2022
Accepted:
October 20,
2022
Received in revised form:
October 2,
2022
Received:
August 23,
2022
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106856
Copyright
© 2022 Elsevier Inc. All rights reserved.
