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Prediction of cerebral hyperperfusion following carotid endarterectomy using intravoxel incoherent motion magnetic resonance imaging

      Abstract

      Objectives

      One of the risk factors for cerebral hyperperfusion following carotid endarterectomy (CEA) is a chronic reduction in cerebral perfusion pressure due to internal carotid artery (ICA) stenosis, which is clinically detected as increased cerebral blood volume (CBV). The perfusion fraction (f) is one of the intra-voxel incoherent motion (IVIM) parameters obtained using magnetic resonance (MR) imaging that theoretically reflects CBV. The present study aimed to determine whether preoperative IVIM-f on MR imaging predicts development of cerebral hyperperfusion following CEA.

      Materials and Methods

      Sixty-eight patients with unilateral ICA stenosis (≥ 70%) underwent preoperative diffusion-weighted 3-T MR imaging, and IVIM-f maps were generated from these data. Quantitative brain perfusion single-photon emission computed tomography (SPECT) was performed before and immediately after CEA. Regions-of-interest (ROIs) were automatically placed in the bilateral middle cerebral artery territories in all images using a three-dimensional stereotactic ROI template, and affected-to-contralateral ratios in the ROIs were calculated on IVIM-f maps.

      Results

      Nine patients (13%) exhibited postoperative hyperperfusion (cerebral blood flow increases of ≥ 100% compared with preoperative values in the ROIs on brain perfusion SPECT). Only high IVIM-f ratios were significantly associated with the occurrence of postoperative hyperperfusion (95% confidence interval, 253.8–6774.2; p = 0.0031) on logistic regression analysis. The sensitivity, specificity, and positive and negative predictive values of the IVIM-f ratio to predict the occurrence of postoperative hyperperfusion were 100%, 81%, 45%, and 100%, respectively.

      Conclusions

      Preoperative IVIM-f on MR imaging can predict development of cerebral hyperperfusion following CEA.

      Keywords

      Abbreviations:

      CEA (carotid endarterectomy), CBF (cerebral blood flow), ICA (internal carotid artery), CBV (cerebral blood volume), MR (magnetic resonance), IVIM (intra-voxel incoherent motion), DWI (diffusion-weighted magnetic resonance imaging), f (perfusion fraction), SPECT (single-photon emission computed tomography), 123I-IMP (iodine 123 N-isopropyl-p-iodoamphetamine), ROI (region-of-interest), MCA (middle cerebral artery), ROC (receiver operating characteristic), CIs (confidence intervals)
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