Abstract
Purpose
Many studies have shown that cytochrome P450 (CYP) gene polymorphisms are usually
associated with an increased risk of cardiovascular and cerebrovascular diseases.
To explore the association of CYP2C8 and CYP2J2 gene polymorphisms with hypertensive
intracerebral hemorrhage (HICH) in the Han Chinese population.
Methods
Forty HICH patients and 40 control subjects were recruited for this study. Two single
nucleotide polymorphisms (SNP) (rs1058932, rs2275622) in the CYP2C8 gene and two SNPs
(rs2271800, rs1155002) in the CYP2J2 gene were selected for genotyping by direct sequencing.
Statistical analysis was applied to examine the effect of genetic variation on HICH.
Results
We found that variant alleles of CYP2C8 rs1058932 (A) and rs2275622 (C) were both
significantly associated with HICH, especially in females. We also found significant
associations of CYP2C8 rs1058932 (A) and rs2275622 (C) variant alleles with poor outcomes
in HICH patients, especially in males.
Conclusions
CYP2C8 gene polymorphisms might increase the risk of HICH in the Han Chinese population
and might lead to poor outcomes. This finding adds to the body of literature supporting
novel therapeutic strategies for HICH.
Keywords
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Article info
Publication history
Published online: December 31, 2022
Accepted:
December 27,
2022
Received in revised form:
December 11,
2022
Received:
October 6,
2022
Footnotes
Our work was performed in Linyi People's Hospital.
Funding: This research was supported by a grant from Linyi Science and Technology Development Program, China (201919010).
Identification
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106974
Copyright
© 2022 Elsevier Inc. All rights reserved.
