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Indicators of an acute phase response (APR) in acute ischemic stroke have been shown
to correlate with infarct size and predict stroke recurrence. In this study, we examined
how well the APR indicators predicted long-term stroke recovery compared with standard
clinical predictors of recovery. Plasma levels of interleukin-6 (IL-6), fibrinogen,
white blood cells (WBCs), and serum albumin were measured within 4±2 days of onset
in 131 stroke patients who were free of apparent infections. Standard clinical predictors
included initial National Institutes of Health Stroke Scale (NIHSS), infarct size
on computed tomography (CT), and Glasgow scale. The individual correlations with 6-month
Glasgow outcome were IL-6, 0.42; fibrinogen, 0.24; WBC, 0.35; albumin, 0.47; NIHSS,
0.53; infarct size, 0.19; and initial Glasgow, 0.57. (all P<.005). Multiple regression analysis yielded an adjusted R2 of .31 for the APR indicators, compared with .38 for the clinical variables. These
results indicate that the initial APR is highly correlated with 6-month stroke recovery
and that this correlation approaches that observed with standard clinical predictors.
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Article info
Publication history
Accepted:
September 25,
1997
Received:
June 23,
1997
Footnotes
†Supported in part by an NIH:CIDA award (W.M.C.); and NINDS 2PO1 NS17493-08 (B.M.C.).
Identification
Copyright
© 1998 National Stroke Association. Published by Elsevier Inc.
